Windows 7 and Vista have all the same Windows+X shortcut keys as other versions of Windows, such as Win+E for explorer and Win+D for the desktop, but adds in all of the Win+<num> keys to launch the shortcuts in the Vista Quick Launch menu (or switch to apps in Windows 7), as well as Win+X for mobility center, etc. But what if you want to disable all these extra keys?
Manual Registry Hack
Just open up regedit.exe through the start menu search box and navigate to the following key (create if it doesn’t exist)
Create a 32-bit DWORD value called NoWinKeys and set the value to 1. You’ll need to log on and back off for the changes to take effect.
Make sure that you log off and back on in order for this change to take effect. You could also restart explorer.exe through task manager if you wanted.